GSK is a global biopharma company aiming to positively impact the health of 2.5 billion people by the end of the decade. They are seeking a Postdoctoral Researcher in Quantitative Systems Pharmacology to build mechanistic mathematical models and collaborate with multidisciplinary teams to inform drug development and research programs.
Responsibilities
- Build mechanistic mathematical models of biological, physiological, and pathophysiological processes to evaluate disease, its pathways and progression as well as drug action to prevent, treat and cure diseases; and conduct simulations of virtual patients to inform target and/or asset prioritization and optimal trial design
- Develop and/or utilize state-of-the-art mathematical tools including knowledge of non-linear dynamics, scientific ML and/or statistical techniques to gain insight into causal relationships between individual components of system-level and drug-level responses of drug-target-biomarker-disease-patient interaction
- Identify relevant question(s) of interest by working with disease area experts across different disciplines and address the question(s) by applying mechanistic and systems modelling
- Communicate and work in close collaboration with clinicians, biologists, clinical pharmacologists, pharmacometricians, statisticians, AIML, imaging, biomarker, genomics scientists and other cross-matrix colleagues to inform research and development programs and improve our understanding of disease mechanisms
- Promote transparency and communicate R&D achievements through publications in appropriate scientific journals
Skills
- PhD, MD, or PharmD with experience in mechanistic modelling and simulation and systems biology
- Strong drive to quickly learn and build knowledge on a drug-disease system, the mechanism, endpoints, progression, prevention, treatments, and trial design
- Strong communication skills and demonstrated ability to work in a multi-discipline team, using effective communication and taking personal accountability for timely delivery of results
- Prior experience with applications in pharmaceutical research and development is a plus
- Prior experience in Respiratory (e.g. COPD, IPF), Renal (e.g. CKD, nephrotoxicity), Hepatology (e.g. MASH) and/or Infections diseases (e.g. HBV) is a plus
Benefits
- Annual bonus based on company performance
- Healthcare and wellbeing programmes
- Pension plan membership
- Shares and savings programme
- Health care and other insurance benefits (for employee and family)
- Retirement benefits
- Paid holidays
- Vacation
- Paid caregiver/parental and medical leave
Company Overview
We are uniting science, technology and talent to get ahead of disease together. Our community guidelines: https://gsk.to/socialmedia It was founded in 1929, and is headquartered in London, England, GBR, with a workforce of 10001+ employees. Its website is http://www.gsk.com.Company H1B Sponsorship
GSK has a track record of offering H1B sponsorships, with 45 in 2025, 56 in 2024, 54 in 2023, 53 in 2022, 54 in 2021, 72 in 2020. Please note that this does not guarantee sponsorship for this specific role.
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