About the position
Legend Biotech is seeking a Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology) as part of the Early Drug Development team based in Somerset, NJ. We are seeking a highly motivated and innovative Principal Scientist to join our immunology and immuno-oncology (IO) clinical biomarker projects, with a dedicated focus on hematological malignancies. In this role, you will drive the clinical translational understanding of novel therapy in hematology. You will serve as the biology lead on cross-functional project teams, drive MOA of novel cell therapy and clinical biomarker strategy.
Responsibilities
• Design, execute, and analysis results from clinical studies to investigate the mechanisms of action for novel IO targets in hematological indications (e.g., AML, DLBCL, Multiple Myeloma).
• Bridge discovery and clinical development by utilizing primary human samples and clinical datasets to validate targets and understand the immune microenvironment in hematology.
• Oversee the generation and interpretation of high-dimensional molecular and cellular data.
• Leverage advanced single-cell technologies (e.g., scRNA-seq) to deeply profile immune cell compartments, particularly T-cell states and exhaustion markers, to inform patient stratification and biomarker hypotheses.
• Partner closely with other functional teams for better understanding of MOA and fundamental immunology.
Requirements
• Ph.D. in Immunology, Immuno-Oncology, Cellular Biology, or a closely related discipline, can initiate and lead data driven MOA studies.
• A minimum of 5-8+ years of post-doctoral and/or industry experience in biotech or pharma, with a proven track record of advancing IO programs.
• Deep understanding of immunology, particularly T cell biology highly desirable.
• Deep biological understanding of hematological malignancies and the unique tumor immune microenvironment of the blood and bone marrow.
• Experience working with multiple dimensional data, extract biological insights from data highly desirable.
• Exceptional written and verbal communication skills, with the ability to distill complex data into clear, actionable strategic decisions.
Nice-to-haves
• Experience with cell therapy a plus but not required.
Benefits
• Medical, dental, and vision insurance
• 401(k) retirement plan with a company match that vests fully on day one
• Eight (8) weeks of paid parental leave after just three (3) months of employment
• Paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays
• Flexible spending and health savings accounts
• Life and AD&D insurance
• Short- and long-term disability coverage
• Legal assistance
• Supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance
• Voluntary commuter benefits
• Family planning and care resources
• Well-being initiatives
• Peer-to-peer recognition programs