Note: The job is a remote job and is open to candidates in USA. Natera is a global leader in cell-free DNA testing, dedicated to oncology, women’s health, and organ health. The Senior Director Clinical Biomarkers will provide strategic, scientific, and organizational leadership across a broad oncology diagnostics portfolio, focusing on biomarker and translational medicine strategies in BioPharma collaborations.
Responsibilities
- Lead translational medicine and clinical biomarker strategy across oncology programs within and beyond the BioPharma BD portfolio
- Define and oversee biomarker plans supporting late-stage development in solid tumors within the BioPharma space (Pharma Lab Services, BD partnerships) including assay strategy, translational endpoints, data generation, data interpretation, publication planning, and regulatory filing support
- Partner closely with clinical development, bioinformatics, medical affairs, regulatory, diagnostics, and commercial teams to ensure assay development portfolio and biomarker strategies are aligned with overall BioPharma BD needs
- Work with external partners on their Natera-supported translational research efforts to help them leverage Natera capabilities to optimize the value of their projects: these may include identifying novel targets, characterizing resistance mechanisms, developing novel predictive biomarkers and next-generation clinical tools, including blood-based biomarkers, digital pathology, radiomics, and AI/ML-enabled approaches
- Support development and lifecycle strategies that enable successful product differentiation, launch readiness, reimbursement, and broader clinical adoption
- Contribute to study design and evidence-generation plans that support our BioPharma efforts across BD, Pharma Lab Services, and internal R&D
- Work with the RWD, AI, and bioinformatics teams to develop use cases for existing data and build out new concepts for new data types as they are created
- Apply translational insights to inform patient selection, development decisions, and clinical differentiation strategies for our customers
- Establish and lead strategic collaborations with BioPharma partners, academic institutions, cooperative groups, scientific consortia, and key opinion leaders
- Represent the company in external scientific and clinical initiatives that shape the future of biomarker-enabled oncology development
- Build productive external partnerships that accelerate innovation, evidence generation, and adoption of novel translational approaches
- Serve as a visible scientific leader through publications, invited presentations, advisory participation, and broader thought leadership in oncology and precision medicine
- Maintain strong credibility in the external scientific community, with the ability to engage effectively with academic leaders, consortia, and industry partners
- Contribute to the company’s scientific reputation through high-impact external presence and publication strategy
Skills
- Deep expertise in oncology drug development, biomarker strategy, and translational research
- Experience spanning Phase 1–3 studies and multiple therapeutic modalities, including immunotherapy, targeted therapy, and antibody-drug conjugates
- Ability to lead translational medicine and clinical biomarker strategy across oncology programs
- Define and oversee biomarker plans supporting late-stage development in solid tumors
- Partner closely with clinical development, bioinformatics, medical affairs, regulatory, diagnostics, and commercial teams
- Work with external partners on Natera-supported translational research efforts
- Support development and lifecycle strategies that enable successful product differentiation, launch readiness, reimbursement, and broader clinical adoption
- Contribute to study design and evidence-generation plans that support BioPharma efforts
- Work with RWD, AI, and bioinformatics teams to develop use cases for existing data
- Apply translational insights to inform patient selection, development decisions, and clinical differentiation strategies
- Establish and lead strategic collaborations with BioPharma partners, academic institutions, cooperative groups, scientific consortia, and key opinion leaders
- Represent the company in external scientific and clinical initiatives
- Build productive external partnerships that accelerate innovation, evidence generation, and adoption of novel translational approaches
- Serve as a visible scientific leader through publications, invited presentations, advisory participation, and broader thought leadership in oncology and precision medicine
- Maintain strong credibility in the external scientific community
- Advanced degree in a relevant scientific discipline; PhD, MD, DVM, or equivalent strongly preferred
- 15+ years of relevant experience in translational medicine, clinical biomarker development, oncology drug development, or related fields
- Significant experience in biomarker-driven clinical development and medical affairs across early- and late-stage oncology programs
- Demonstrated success in building external scientific relationships and representing organizations in high-profile external settings
- Strong record of scientific leadership, cross-functional collaboration, and strategic execution
Benefits
- Annual performance incentive bonus
- Long-term equity awards
- Comprehensive health benefits (medical, dental, vision)
- 401(k) with company match
- Generous paid time off and company holidays
- Additional wellness and work-life benefits
- Comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents
- Free testing in addition to fertility care benefits
- Pregnancy and baby bonding leave
- 401k benefits
- Commuter benefits
- Generous employee referral program
Company Overview
Company H1B Sponsorship