Note: The job is a remote job and is open to candidates in USA. Pfizer is a leading pharmaceutical company committed to improving global health. The Senior Director, IM Portfolio Strategy Lead will be responsible for leading portfolio-level strategy and investment decision support across the Internal Medicine and Antivirals portfolio, leveraging deep commercial strategy experience and analytical skills to shape portfolio choices and strategic recommendations.
Responsibilities
- Lead development of long-range commercial and portfolio strategy across the Internal Medicine and Antivirals portfolio, spanning pipeline assets, lifecycle opportunities, external innovation, and emerging disease-area opportunities
- Establish integrated near-, mid-, and long-term views of portfolio opportunities, risks, and investment priorities to inform enterprise decision-making
- Synthesize scientific, clinical, commercial, access, competitive, financial, and patient insights to identify priority opportunities and strategic trade-offs
- Monitor shifts in the scientific, competitive, and market landscape to identify emerging trends, discontinuities, and implications for future Internal Medicine and Antivirals strategy
- Translate portfolio strategy into clear recommendations, implications, and decision materials for leadership, governance forums, and cross-functional portfolio discussions
- Provide senior commercial strategy leadership for portfolio prioritization, investment choices, and development opportunities across Internal Medicine and Antivirals priorities
- Pressure-test commercial assumptions, value drivers, risks, uncertainties, resource implications, and evidence needs that may influence future launch potential, lifecycle value, and portfolio performance
- Lead development of executive-ready materials that communicate strategic rationale, opportunity attractiveness, trade-offs, scenarios, and recommended actions
- Partner with cross-functional leaders to align on key choices related to portfolio sequencing, indication prioritization, evidence generation, market development, and lifecycle opportunities
- Support disciplined decision-making by ensuring portfolio recommendations are grounded in patient need, scientific opportunity, market potential, access dynamics, financial impact, and enterprise value
- Oversee early commercial assessments for pipeline assets, mechanisms, indications, disease-area opportunities, and potential future product concepts across Internal Medicine and Antivirals
- Guide development and refinement of product concepts, target product profile input, positioning hypotheses, market archetypes, commercial opportunity assessments, and forecast assumptions
- Ensure unmet need, standard of care, competitive dynamics, patient/HCP insights, payer considerations, and access requirements are translated into differentiated commercial hypotheses
- Provide portfolio-level commercial input to clinical development, evidence generation, lifecycle, and indication sequencing discussions in partnership with cross-functional colleagues
- Build repeatable approaches for high-quality early commercial strategy outputs, portfolio reviews, and decision-support materials across Internal Medicine and Antivirals workstreams
- Lead portfolio strategy input for external innovation and Business Development opportunities relevant to Internal Medicine and Antivirals
- Guide assessment of strategic fit, market potential, valuation inputs, competitive scenarios, portfolio implications, and prioritization considerations for potential external opportunities
- Partner with Business Development, R&D, GASP, BAI, and Competitive Intelligence colleagues to pressure-test assumptions and identify key decision points
- Represent the commercial portfolio strategy perspective in internal discussions related to external opportunities and broader Internal Medicine and Antivirals strategy as needed
- Provide senior matrix leadership across cross-functional partners, helping align priorities, clarify decision points, and strengthen high-quality strategic outputs across Internal Medicine and Antivirals portfolio priorities
- Partner with the VP, GCS, IM/AV, DALs, and cross-functional leaders to ensure a strong commercial and portfolio strategy voice is incorporated into early development, portfolio, and investment decisions
- Influence without direct authority by aligning stakeholders around shared insights, strategic choices, and implications for the Internal Medicine and Antivirals portfolio
- Build trusted working relationships across R&D, Medical Affairs, GASP, BAI, Competitive Intelligence, Business Development, Finance, and Commercial Regions
- Foster a culture of enterprise thinking, scientific curiosity, disciplined prioritization, accountability, and collaboration across cross-functional workstreams
- Set expectations for responsible, AI-enabled ways of working across portfolio strategy workstreams to improve speed, quality, consistency, and scalability of strategic outputs
- Champion use of AI-enabled tools to support scientific and competitive landscape synthesis, market insight generation, scenario development, prioritization, and decision-support efficiency
- Help build cross-functional capability and confidence in compliant, AI-augmented strategy development through best-practice sharing and reinforcement of quality standards
- Identify opportunities to embed AI into repeatable workflows, templates, portfolio reviews, scenario planning, and strategic decision-support processes
- Use performance insights, stakeholder feedback, and workstream learnings to continuously improve AI-enabled ways of working across portfolio strategy activities
Skills
- Applicant must have a bachelor's degree with at least 12 years of experience; OR a master's degree with at least 10 years of experience; OR a PhD with 7+ years of experience
- Experience in pharmaceutical, biotechnology, life sciences, commercial development, portfolio strategy, corporate strategy, business development, forecasting, market research, analytics, or related field
- Demonstrated experience leading complex cross-functional initiatives, influencing in matrixed environments, and shaping senior-level portfolio or investment decisions without direct authority
- Strong strategic and analytical skills, with ability to synthesize complex scientific, clinical, market, access, and competitive information into clear recommendations
- Experience leading portfolio strategy, early commercial assessment, business case development, opportunity assessment, investment prioritization, or cross-functional strategic planning
- Ability to engage in scientific and clinical dialogue and translate implications for commercial opportunity, differentiation, portfolio value, and enterprise decision-making
- Strong communication, executive presence, problem-solving, and stakeholder management skills
- Experience in Internal Medicine, Antivirals, cardiometabolic disease, specialty care, primary care, or other complex therapeutic areas preferred
- Experience with commercial development, early asset strategy, portfolio management, Business Development assessments, launch strategy, lifecycle strategy, or corporate strategy
- Demonstrated ability to develop long-term strategies for products, disease areas, or portfolios and secure alignment from senior leadership
- Understanding of market access dynamics, payer considerations, evidence generation, value demonstration, and lifecycle value optimization
- Track record of leading cross-functional initiatives, influencing without authority, acting decisively, and making recommendations with incomplete, imperfect or disparate information
- Comfort working in an AI-enabled or AI-augmented environment; experience using AI tools to support strategy, synthesis, or analysis is a plus
- Ability to thrive in ambiguity, operate with enterprise mindset, and adapt to evolving portfolio priorities
- Robust operational experience vis-à-vis building tactical plans to pull through strategic priorities, negotiating the optimal OpEx and A&P investment in the go-to-market model and promotional plan spanning core and innovative commercial levers, and preserving or improving CoGS and gross-to-net liability
- Discretion, sound judgment, and trustworthiness in handling confidential or sensitive organizational matters
Benefits
- Participation in Pfizer’s Global Performance Plan with a bonus target of 22.5% of the base salary
- Eligibility to participate in our share based long term incentive program
- Comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments
- 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
- Paid vacation, holiday and personal days
- Paid caregiver/parental and medical leave
- Health benefits to include medical, prescription drug, dental and vision coverage
- Relocation assistance may be available based on business needs and/or eligibility
Company Overview